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T24557 |
NSC756093
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NSC-756093,NSC 756093 |
Others
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NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies. |
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T6207 |
SC144
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Apoptosis
,
Interleukin
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SC144 is an orally active small-molecule gp130 inhibitor. |
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T2679 |
BMS-265246
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BMS265246 |
CDK
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BMS-265246 is a potent and selective CDK1/2 inhibitor. |
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T2617 |
SNS-314 Mesylate
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SNS-314 |
Aurora Kinase
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SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2. |
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T12238 |
NNC 55-0396
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NNC 55-0396 dihydrochloride |
Calcium Channel
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NNC 55-0396 is a highly selective blocker of T-type calcium channel with IC50 of 6.8 μM. NNC 55-0396 can be used in studies about preventing human ovarian cancer cell proliferation. |
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T34262 |
RAPTA-C
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Apoptosis
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RAPTA-C induces EAC cell cycle arrest and apoptosis via the mitochondrial and p53-JNK pathways, and can be used in the study of breast and ovarian cancer. |
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T67741 |
SU056
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Others
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SU056 is a YB-1 inhibitor. SU056 interacts with YB-1 and inhibits and downstream proteins and pathways. SU056 can induce cell-cycle arrest, apoptosis, and inhibit cell migration in ovarian cancer cells. |
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T16680 |
PTC-028
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Apoptosis
,
BMI-1
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PTC-028 selectively suppresses cancer cells whereas normal cells remain unaffected. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. The depletion of BMI-1 by PTC-028 causes caspas... |
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T60039 |
KSQ-4279
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USP1-IN-1 |
PARP
,
DUB
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KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine and pancreatic ... |
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T8464 |
RA-9
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Apoptosis
,
DUB
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RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines. |
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T16328 |
Nitroaspirin
|
NCX 4016 |
Apoptosis
,
COX
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Nitroaspirin (NCX 4016) is a nitric oxide donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin induces significant induction of cell cycle arrest and apoptosis... |
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T36674 |
DMU-212
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Apoptosis
,
ERK
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DMU-212 is a methylated derivative of Resveratrol , with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2... |
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T71998 |
673-A
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673-A is an aldehyde dehydrogenase (ALDH1A) inhibitor that depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. 673-A triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupli... |
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T24879 |
Thioxodihydroquinazolinone-19
|
Thioxodihydroquinazolinone19 |
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In platinum-resistant A2780cis human ovarian cancer cells, thioxodihydroquinazolinone-19 is an inducer of apoptotic cell death. It acts by exhibiting a strong inhibitory effect in ovarian CSC-LCs in combination with cisp... |
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T41070 |
LP-184
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|
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LP-184 (Compound 6), referred to as an acylfulvene analog, demonstrates the ability to inhibit tumor growth with noteworthy anti-cancer efficacy observed across multiple cell lines, including ovarian, colon, prostate, an... |
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T21324 |
R306465
|
R-306465,JNJ 16241199,R 306465,JNJ-16241199,JNJ16241199 |
|
|
R306465 is a potent inhibitor of HDAC1 and -8 (class I) in vitro. It potently inhibited cell proliferation of all main solid tumour indications, including colon, ovarian, breast, lung and prostate cancer cell lines with ... |
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TP1427 |
ReACp53
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|
|
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ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC). |
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T36700 |
CKD 602
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|
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Topoisomerase I inhibitor. Forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. Inhibits growth of a range of cancer cell lines in vitro, as well as of ovarian ... |
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T15723 |
LBW242
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|
Others
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LBW242 is a 3-mer and Smac mimetic and is an effective and orally active proapoptotic IAP inhibitor. LBW242 has activity against multiple myeloma and potentiates TRAIL- and anticancer drug-mediated cell death of ovarian ... |
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T36449 |
(S)-α-Methylbenzyl Ricinoleamide
|
|
|
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(S)-α-Methylbenzyl ricinoleamide is a fatty acid amide derived from ricinoleic acid and methyl benzylamine. It demonstrates potent growth inhibition of glioma (U251), breast (MCF-7), ovarian (NCI-ADR/RES and OVCAR-3), ki... |
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T79315 |
PROTAC TG2 degrader-2
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PROTACs
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PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM. It inhibits cell migration and reduces TG2 levels in ovaria... |
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T71549 |
RKS-262
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|
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RKS262 is a specific cyclin/CDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cell-line as... |
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T71099 |
LLL12
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|
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LLL12 is a small molecule inhibitor of STAT3 that inhibits STAT3 phosphorylation. LLL12 enhanced the inhibitory effect of Cisplatin and Paclitaxel on ovarian cancer cell formation, migration, and growth [1] . |
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T71218 |
AEZS-112
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|
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AEZS-112, also known as ZEN012, is an orally active small mol. anti-cancer drug which inhibits the polymn. of tubulin at low micromolar concns. AEZS 112 dose-dependently increased non-vital hypodiploid cells and the cyto... |
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T78296 |
IMAB027
|
ASP1650 |
|
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IMAB027 (ASP1650) is a specific monoclonal antibody targeting CLDN6 (Claudin 6), a membrane protein of tight junctions aberrantly overexpressed in multiple human cancers, notably in ovarian cancers. This compound exhibit... |
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T71287 |
CDKI-83
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|
|
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CDKI-83 is a potent CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 <1 μM, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determi... |
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T82605 |
DB21, Galectin-1 Antagonist
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Galectin
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DB21, Galectin-1 Antagonist, is a peptidomimetic conjugated with dibenzofuran, serving as an allosteric inhibitor of galectin-1 (GAL1) interactions with glycans on cell surfaces. This compound enhances the inhibition of ... |
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T36846 |
Chromomycin A2
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|
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Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities. Chromomycin A2 inhibits the growth of B. subtilis in an agar diffusion assay. It als... |
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T69055 |
PD153035 nitrate
|
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PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in ... |
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T71811 |
Lobaric acid
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Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-f... |
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T36404 |
PRLX-93936
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|
|
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PRLX-93936 is an analog of erastin that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay). PRLX-93936 (1... |
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T83938 |
TAT-PDHPS1
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|
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TAT-PDHPS1 is a peptide inhibitor targeting Yes-associated protein (YAP) signaling, composed of the endogenous peptide PDHPS1 and the cell-penetrating peptide sequence TAT. It operates by binding to protein phosphatase 2... |
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T72630 |
BRD4 Inhibitor-25
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|
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BRD4 Inhibitor-25, a chemical compound targeting the BD1 and BD2 domains of BRD4 with half-maximal inhibitory concentrations (IC50s) of 0.82 μM and 1.94 μM respectively, demonstrates efficacy in inducing apoptotic and au... |
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T36701 |
Phosphoramide mustard (cyclohexanamine)
|
|
|
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Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA d... |
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T83921 |
IMCTA-C14 TFA
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|
|
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IMCTA-C14, a detergent and derivative of the microbial metabolite 4-trehalosamine, exhibits a critical micelle concentration (CMC) of 0.11 mM and a hydrophilic-lipophilic balance (HLB) value of 9.72. It effectively extra... |
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T63351 |
MS8511
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|
|
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MS8511, a selective covalent irreversible inhibitor of G9a/GLP, targets a cysteine residue at the substrate binding site, displaying IC50 values of 100 nM (G9a) and 140 nM (GLP), alongside Kd values of 44 nM (G9a) and 46... |
